JDRF Studies Biomedical Implant Immune Responses


Image: .jdrf.org

An accomplished otolaryngologist based in Marianna, Florida, Dr. Angelo Consiglio maintains a private practice where he treats major sinus issues and other ear, nose, and throat problems. Engaged with his community, Angelo Consiglio, MD, supports a number of nonprofit organizations, including the Juvenile Diabetes Research Foundation.

A recent study sponsored by the Juvenile Diabetes Research Foundation and the Harry B. Helmsley Charitable Trust has discovered new information about how the body deals with foreign materials introduced through medical implants, such as insulin pumps. The research for this study was conducted by professionals at the Boston Children’s Hospital as well as the Massachusetts Institute of Technology.

In studying rodents and animal primates, researchers found that colony stimulating factor-1 receptors increased their immunological activity when implanted devices made of materials such as polymer, hydrogel, and ceramic were introduced into the body. They also found that measures that singled out these receptors were able to help these implants become more compatible with the body’s immune system, and also promoted a more complete healing of wounds due to the lessening of fibrosis.